Iodine Deficiency Disorders in Indonesia: Past, Present, and Future

Ares S, Escobar-Moreale HF Quero J et al. Neonatal hypothyroxinemia:effects of iodine intake and prema ture birth. J

Clin Endcinol Metab 82 ; 1704-12, 1997

Bambang - Hartono. Minimal Brain Damage (MBD) dan Gangguan Akibat Kurang lodium (GAKI). (Minimal brain damage

and IDD). Editors Djokomoeljanto, Darmono, Tony Suhartono: Ill National Thyroid Meeting, Semarang 1996, page 37.

Bambang - Hartono. The influence of iodine deficiency during pregnancy on neurodevelopment from birth to two years.

Academisch proefschrift. Sept 5, 2001, Free University , Amsterdam.

Benny Kodyat, Djokomoeljanto, Darwin Karyadi, Tarwoljo, Muhi/al, Husaini andAsmira Sukaton Micronutrient

Malnutrition. Intervention program. An Indonesian experience. Min of Health, Dir Gen Community Health, Directorate of

Community Nutrition 1991.page 26

8/eichrodt N, Garcia I, Rubio C et al. Developmental disorders associated with severe iodine deficiency. The prevention

and control of Iodine Deficiency Disorders. Ed:BS Hetzel, JT Dunn and JB Stanbury. Elsevier 1987, page 65

8/eichrodt N, Born M Ph. A metaanalysis of research on Iodine and Its relationship to cognitive development. The

damaged brain of iodine deficiency. Ed JB Stanbury Cognizant Communication Co , New York, Sydney Tokyo, 1994,

page 195.

Boyages S. The damaged brain of Iodine deficiency: evidence for a continuum of effect on the population at risk. 1994,

Idem , page 251.

Calvo RM, Juaniaux E, Gu/bis 8 et al. Fetal tissues are exposed to biologically relrvant free thyroxine concentrations

during early phases of development. J Clin Eendocrinol Meta 87; 1768-1777, 2002

Cao XY, Jiang XM, Dou ZH et al. Timing of vulnerability of the brain to iodine deficiency In endemic cretinism . N Engl J

Med 1994 ; 331 : 1739.

Choufoer JC, van Thijn M, Querido A. Endemic goiter in Western New Guinea : II. Clinical picture , incidence and

pathogenesis of endemic cretinism. J Clin Endocrinol Metab 25, 385, 1965.

Cobra C, Muhi/a/ , Rusmi Ket al. Infant survival is improved by oral iodine supplementation. J Nutr 127 ; 574-578, 1997

Contempre 8, Many MC, Vanderpas J, Dumont JE. Interaction between two trace elements: selenium and iodine.

Implications of both deficiencies.in :The damaged brain of iodine deficiency. Cognitive, behavioral, neurornotor and

educative aspects. Ed JB Stanbury. Cognizant Commuincation Corporation, New York Sydney Tokyo 1994, page 133.

Delange FM. Relation of thyroid hormones to human brain development. In: Fetal brain disorders- recent approaches to

the problem of mental deficiency. Eds. BS Hetzel, RM Smith, CSIRO Adelaide, Elsevier North Holland, 1981, page 285

Delange F. Anomalies in physical and intellectual development associated with severe endemic goitre. In: JT Dunn et al

(editors): Endemic goiter, cretinism and iodine deficiency.PAHO Scientific Publ. No 502, Washington DC, 1986 :

page 49-67.

Delange F. Effect of maternal thyroid function during pregnancy on fetal developmment. In "The Thyroid And Pregnancy"

International MERCK - Symposium in Brussels 1991, Eds: C Beckers and D. Reinwein. Schattauer Stuttgart - New York,

Delange F. Screening for congenital hypothyroidism used as an indicator of the degree of iodine deficiency and its control.

Thyroid, 1998 ; 8: 1185.

Delange F. Neonatal thyroid screeing as monitoring tool for the control of iodine deficiency. Acta Paediatr Suppl 432 : 21-

, 1999

Delong RG. The effect of iodine deficiency on neuromuscular development IDD Newsletter, August 1990.

Delong GR. Observation on the neurology of Endemic cretinism. In Iodine and the Brain. Edijors: Delong, Robbins and

Gondliffe. Plenum Press New York, 1989 page 231.

De Nayer, Dozin 8. Thyroid hormones and the brain. in the Thyroid and TlSSues. Merck European Sympsosium

Strasbourg 1994, eds: Orgiazzi J, Leclere J, Hostalek U. Scattauer 1994

Dept of Health, Jakarta 1992. Guidelines for the distribution and dose ofyodiol capsules.

Deparlemen Kesehatan - Badan Pusat Statistik. Hasil Survei Konsumsi Garam Yodium Rumah Tangga 1998. Badan

Pusat Statistik dengan Departemen Kesehatan ,Jakarta Agustus 1998.

Deparlemen Kesehatan RI. Laporan Akhir. Bantaun Tehnis untuk Studi Evaluasi Proyek lntensifikasi Penanggulangan

Gangguan Akibat Kekurangan Yodium (IP-GAKY). 2005

Dini K Latief. Program of the Elimination of Iodine Deficiency Disorders. Towards the absence of newborn cretins by the

year 2000 in Indonesia. 1st Workshop on Measures Against Iodine Deficiency Disorders, Japan International Corporation

of Welfare Services, Tokyo Dec 1997

Dini K Latief MSc. Program lntensifikasi Penanggulangan Gangguan Akibat kekurangan Yodium di Indonesia, Disajikan

pada Konsultasi Managemen GAKY Regional Ill di Bukitttinggi, Sumatera Baral, 1 Febr, 2000.

Djokomoelfanto R. The effect of severe iodine deficiency : a study on a population in Central Java Indonesia. Doctoral

dissertation, Diponegoro University Semarang Indonesia, 1974.

Djokomoelfanto R. Goiter mapping and IDD in Central Java. Media Medika lndonesiana (1997) 32: 1.

Djokomoelfanto R, Setyawan H, Dramaix M, Hadisaputro S, Soehartono T, Delange F. The Thyrornobil model for

standardized evaluation of Iodine Deficiency Disorder Control in Indonesia. THYROID ; 11 : 365, 2001.

Djumadias A, Latinulu S, Sumamo /, Syafrudin, Sudjono M. Studi Penilaian terhadap Gangguan Akibat Kekurangan

lodium di propinsi Jawa Baral, 1996.

Escobar GM de , Obregon MJ, Calvo R, Escobar def Rey F. Effects of iodine deficiency on thyroid hormone metabolism

and the brain fetal rats:role of the maternal transfer of thyroxin. Am J Clin Nutr Suppl; 57:280 S, .1993.

Escobar GM de, Obregon MJ, Escobar def Rey. Is neurophysiological development related to maternal hypothyroidism or

lo maternal hypothyroxinemia ? J Clin Endocrinol etab 85; 3975, 2000

Escobar GM, Escobar def Rey F. Consequences of Iodine Deficiency for Brain Development. In: The Thyroid and Brain.

Eds. Morreale de Escobar, de Vijlder, S Butz and U Hostalek. Merck European Thyroid Symposium, Seville, May 30,

Scahattauer 2003 page 33,,

Glinoer D, Delange F. The potential Repercussions of Maternal , Fetal and Neonatal Hypothyroxinemia on The progeny.

Thyroid 10: 871, 2000

Goslings BM, Djokomoeljanto R, Hoedijono R, Soepardjo H, Querido A. Studies on hearing loss in a community with

endemic cretinism in Central Java, Indonesia. Acta Endocrinol ( Copenh) 1975: 78(4) : 705

Gos/ings BM,Djokomoeljanto R, van Hardeveldt et al. Hypothyroidism in an area of endemic goiter and cretinism in

Central Java, Indonesia. J Clin Endocrinol Metab,44:481, 1977.

Halpern JP. The neuromotor deficit in endemic cretinism and its implications for the pathogenesis of the disorder. The

Damaged Brain of Iodine Deficiency, Ed JB Stanbury, Cognizant Communication Co. New York Sydney Tokyo 1994

page 15.

Heindel JJ, Zoeller RT. Thyroid hormone and brain development : translating molecular mechanisms to population risk.

Guest Editorial. THYROID, 13 : 1001, 2003

Hetzel BS. A review of the control program for endemic goitre and endemic cretinism. First National Seminar on Endemic

Gorter and Cretinism. Diponegoro Medical School - Dr Kariadi Hospital, Semarang Dec, 1978 page 176.

Hetzel BS and Querido A. Iodine deficiency, thyroid function and brain development. In: Endemic Goiter and endemic

Cretinism. Iodine Nutrition in Health and Disease. Eds JB Stanbury and BS Hetzel. A Wiley Med Public John Wiley &

Sons Inc, 1980, page 461

Hetzel BS. Historical developments of the concepts of brain-thyroid relationship. in: The damaged brain of iodine

deficiency.Ed:JBStanbury. Cognizant Communication Corp. New York-Sydney-Tokyo, 1994, page1

Hume R, Simpson J, Delahunty C et al. Human Fetal and cord serum thyroid hormones: developmental trends and

interrelationships. J Clin Endocrinol Metab 89; 4097-4103, 2004

Jones SA, Thoemke KR, Anderson GW. The role of thyroid hormone in fetal and neonatal brain development . Curr Opin

Endocrinol Diabetes 12 : 10-16, 2005.

Leonard JL. Regulation of T3 production in the brain. 4th Thyroid Symposium Brain and Thyroid, Graz-Austria, Acta

Medica Austriaca, 1992, Sonderheft1, vol 19: page 5

McMichael AJ, Porter JD, Hetzel BS.Iodine Deficiency, Thyroid Function and Reproductive Failure. In: Endemic Goiter

and Endemic Cretinism, eds. Stanbury and Hetzel. John Wiley and Sons, 1980, p 445.

Meinhold H, Campos-Barros A, Behne D. Effects of selenium and iodine deficiency on iodothyronine deiodinases in brain,

thyroid and peripheral tissue, 4th Thyroid Symposium Brain and Thyroid, Graz-Austria, Acta Medica Austriaca, 1992,

Sonderheft1, vol 19: page 8

Muhi/al et al. Final Report. National Survey for Mapping of Iodine Deficiency Disorders (100). Collboration between

Nutrition Research and Development Centre and Directorate of Community Nutrition, Ministry of Health. 1998.

Obregon MJ, Calvo RM, Escobar def Rey Fetal. Thyroid hormones and fetal development. In The Thyroid and Age.

Merck Symposium , Italy 1998. Schattauer Stuttgart New York 1998 page 49

Oppenheimer JH, Schwatrz. Molecular basis of thyroid hormone-dependent brain development. Endocrine Reviews, 18:

-475, 1997

Pharoah POD. Delange F, Fierro-benitez , Stanbury J, Endemic cretinism. in Endemic Goiter and Endemic

Cretinism.Iodine Nutrition in Health and Disease. ed: JB Stanbury, BS Hetzel. John Wiley and Sons Inc, 1980, page 395.

Porterfield SP, Hendrich CE. The role of thyroid hormones in prenatal and neonatal neurological development, current

perpectives. Endocrine Review 1993; 14: 94-106.

Potter BJ, McMichael AJ, Hetzel BS.lodization and thyroid status in relation to stillbirths and congenital anomalies. Int J

Epiodemiol 1979; 8 : 137.

Querido A. History of iodine prophylaxis with regard to cretinism and deaf-mutism. In: Human Development and the

Thyroid Gland.Relation to Endemic Cretinism. Ed JB Stanbury and L Kroc. Plenum Press, 1972, page 191

Querido A, 8/eichrodt N, Djokomoeljanto R. Thyroid hormones and Human Mental Development. in Maturation of the

Nervous System, Progress in Brain Research, vol 48, edited by MA Corner et al. Elsevier North Holland Biomedical

Press, page 337, 1978.

Rachmi-Untoro. Summary of 100 Program in Indonesia. Regional Consultation to Promote Sustainaable IDD Program in

SEAR and EMRO, Chiang Mao, Thailand June 2003.

Raja~anavin R, Kewali Unachak, Pradit Winichakoon et al. Neonatal Thyrotropin profile as an index for severity of iodine

deficiency and surveillance of iodine prophylactic program. Thyroid, 1997; 7: 599.

RAN-KPP-GAKY. Rencana Aksi Nasional Kesinambungan Program Penanggulangan Gangguan Akibat Kurang Yodium.

Tim Penanggulangan GAKY Pusat Jakarta, DirJen Binkesmas, Departemen Kesehatan RI, 2005

Reuss ML, Paneth N, Pinto-Martin JA et al. The relation of transient hypothyroxinemia in preterm infants to neurologic

development at two years of age. N Engl J Med 1996; 334: 821-7

SB. Sullivan KM, May W, Nordenberg et al. Use of thyroid stimulating hormone testing in newborns to identify iodine

deficiency. J. Nutr. 127 : 55-58, 1997.

Tarwoljo , Maspaitella F, Soekimo H, Spedarjono, Djokomoeijanto. Goiter prevalence among school age population in

endemic areas of Central Java, Indonesia/ 2nd Asia Oceania Thyroid Assosiaction Meeting, Tokyo, 1982.

Thilly C, Lagasse R, Roger G et I. Impaired fetal and post natal development and high perintal death rate in a severe

iodine deficient area, Thyroid Research VIII, Proc 8th International Congress of Thyroid , Sydney 1980, page 20.

Untoro J. Use of oral iodized oil to control iodine deficiency in Indonesia. PhD dissertation. Agriculture University,

Wageningen, Holland, Febr 17, 1999.

Vanderpas JB, Contempre 8, Duale NI et al. Iodine and selenium deficiency associared with cretinism in northern Zaire.

Am J Clin Nutr 52: 1087, 1990.

Vermiglio F, Lo Presti VP, Moleti Met al. Attention deficit and hyperactivity disorders in the offspring of mothers exposed

to mild-moderate iodine deficiency : a possible novel iodine deficiency disorder in developed countries. J Clin Endocrinol

Metab 89 ; 6054-6060, 2004.

Vulsma T, Gons MH, de Vijlder JJM. Maternal-fetal transfer of thyroxin in congenital hypothyroidism due to a total

organification defect or thyroid agenesis. N Engl J Med 1989 ; 321 : 549-555.

WHOINHD/01.1 Assessment of Iodine Deficiency Disorders and Monitoring thir Elimination. A guide for programme

managers. 2nd edition. ICCIDD, Unicef, WHO, 2001.

Wijaya, Kamilah BR, Moh Effendi. Electroencepahlographic patterns of children in a severe goiter area afterlipiodol

injection. First National Seminar on Endemic goiter and cretinism, Semarang 1978, p.164.

Yasin F. Evaluation fan iodization programs inpregnant women and their babies in Dukun district, Central Java. Thesis

submitted to the University of Western Australia for the degree of M.Med.Sc, 1989.

Zimmermann MB, Kohrle J. The impact of iron and selenium deficiencuies on iodine and thyroid metabolism:

biochemistry and relevance to public health. THYROID; 12 : 867, 2002

Zoeller RT. Thyroid hormones and brain development: environmental influences. Curr Opin Endocribnol Diabetes 12: 31-

, 2005.