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TY - JOUR TI - Hypocholesterol Effect of lndegenous Probiotic Culture and Yoghurt in Sprague Dawley Rats PY - 2023/06/04 Y2 - 2025/09/19 JF - TEMU ILMIAH NASIONAL PERSAGI JA - TINPERSAGI VL - 1 SE - 3. SIMPOSIA TIN PERSAGI 2005 - Pangan Fungsional UR - https://www.tin.persagi.org/index.php/tin/article/view/143 SP - 334-341 AB - Probiotic was believed as an agent of lowering serum cholesterol level. However, the information about this is still controversy. Lactobacillus sp Dad13 is an indigenous probiotic culture isolated from traditional fermented milk. In vitro study proved that Lactobacillus sp Dad13 posseses the ability to assimilate cholesterol and deconjugate bile acids, however in vivo study hasn’t been done yet. The purpose of this research was to study the ability of Lactobacillus sp Dad13 and yoghurt which was supplemented with Lactobacillus sp Dad13 to reduce serum cholesterol level. Twenty four male Sprague Dawley rats, 2 months old were divided into four groups and fed with an AIN-93 diet ad libitum. Rats were fed with standard diet (1 wk) and hypercholesterol diet (1 wk). At the end of the week, lipid profile was measured. Each group were then treated with 10% sterile skimmed milk, as control, Lactobacillus sp Dad13 culture, yoghurt, and yoghurt which supplemented with Lactobacillus sp Dad13 culture 1 ml each. The treatments were given by force feeding. The treatments were assigned for 4 wk and at the end of treatments, serum lipid profile, physical, chemical, and microbiological properties of cecal contents i.e. weight, water contents, pH, cholesterol, and total lactic acid bacteria were analyzed. The results showed that total cholesterol, high density lipoprotein (HDL), triglyceride (TG), low density lipoprotein (LDL), and LDL/HDL ratio decreased significantly (P ER -